Sarah J. Karlen
3301 Tupper Hall
p: (530) 752-6756
Ph.D. in Neuroscience, University of California, Davis
B.S. in Biology, Psychology with Honors, University of Iowa
Sarah’s primary research has focused on the role of the immune system in neurodegeneration, focusing particularly on the significance of resident immune cells (microglia) vs. recruited immune cells (monocytes) during rod photoreceptor degeneration. Additional research projects include determining the effects of prolonged photoreceptor stress on retinal degeneration in the Arrestin knockout model and examining the anatomical changes that occur due to functional loss of the voltage-gated potassium channel 2.1 on rod photoreceptors. Sarah also serves as the Burns & Pugh Lab Manager and safety coordinator.
Prior to becoming a Project Scientist in the Burns & Pugh lab, Sarah completed her PhD and postdoctoral studies at UC Davis. During her PhD studies with Dr. Leah Krubitzer, Sarah investigated cortical plasticity following early visual loss. She received both a Ruth L. Kirschstein National Research Service Award Individual Fellowship and Graduate Research Fellowship from the National Science Foundation, among other honors. During her postdoctoral research with Dr. Barbara Chapman (2008-2012), Sarah studied the effects of retinal activity on the formation of retinocortical connections during early development. As a postdoctoral researcher with Dr. Marie Burns (2015-2016), she examined the role of microglia during retinal detachment and photoreceptor degeneration.
Publications from the Burns & Pugh lab
- Ronning KE, Karlen SJ, Miller EB, and Burns ME. (2019) Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. Sci Rep. Mar 19;9(1):4858. [PubMed]
- Karlen SJ, Miller EB, Wang X, Levine ES, Zawadzki RJ, and Burns ME. (2018) Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration. J Neuroinflammation. Dec 15;15(1):344. [PubMed]
- Goswami M, Wang X, Zhang P, Xiao W, Karlen SJ, Li Y, Zawadzki RJ, Burns ME, Lam KS, and Pugh EN Jr. (2018) Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo. Biomed Opt Express. Dec 11;10(1):151-166. [PubMed]
- Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, and Burns ME. (2017) Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. Journal of Neuroinflammation, 14(121): 1-14. [PubMed]